OT and Social Cognition in Children With ADHD: Impact of MPH
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Background: The current study aimed to explore the possible effect of stimulants on oxytocin
(OT), a neuropeptide found to regulate social behavior, as a mediator of the pro-social
effect of methylphenidate (MPH) in children with attention deficit hyperactivity disorder
(ADHD) compared to healthy controls (HCs). Methods: In a double-blind manner the
investigators compared the performance of 50 children with ADHD and 40 HCs in "theory of
mind" (ToM) tasks and examined the effect of a single dose of MPH/placebo on ToM and salivary
OT levels in children with ADHD at baseline and following an interpersonal interaction.