OT and Social Cognition in Children With ADHD: Impact of MPH

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Background: The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide found to regulate social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls (HCs). Methods: In a double-blind manner the investigators compared the performance of 50 children with ADHD and 40 HCs in "theory of mind" (ToM) tasks and examined the effect of a single dose of MPH/placebo on ToM and salivary OT levels in children with ADHD at baseline and following an interpersonal interaction.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Shalvata Mental Health Center
• Treatments: Methylphenidate

Criteria

Inclusion Criteria:

• Ages 6-12 years

• Diagnosis of ADHD

Exclusion Criteria:

• Past or current affective disorder, psychosis, substance abuse, conduct disorder

• Any medical or neurological condition or medication-taking that might affect the child's participation in the study

• First-degree relative with a major psychiatric diagnosis