OPIOID-FREE ANALGESIA IN ICU IN INTENSIVE CARE UNIT
Status:
Not yet recruiting
Trial end date:
2025-04-01
Target enrollment:
Participant gender:
Summary
ICU patients experience moderate to severe pain. Studies and guidelines point out the
benefits of multimodal analgesia on pain control, opioid spare and on lowering its adverse
effects. However, no recommendation about drugs or protocol has been formulated. In our
study, we studied the feasibility and the impact on Remifentanil spare of a standardized
protocol using multimodal analgesia (Paracetamol, Nefopam, Tramadol, Ketamine, Remifentanil)
compared to the standard-of-care strategy using Paracetamol and Remifentanil. We conducted a
prospective, ''proof of concept'', randomized, double-blind, parallel group,
placebo-controlled trial. We studied multimodal analgesia versus standard-of-care in ICU
patients requiring sedation-analgesia for invasive mechanical ventilation.We hypothesized
that Remifentanil consumption decrease by 15% with the use of a standardized multimodal
analgesia strategy