OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers
Status:
Recruiting
Trial end date:
2024-12-23
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to identify the most effective way to take acid-blocking
medications to treat stomach ulcers in patients who have undergone gastric bypass surgery.
The main questions it aims to answer are:
- is taking an acid-blocking medication by opening the capsule and only taking the
contents of the capsule (open-capsule) more or less effective than taking the capsule as
a whole (intact-capsule) for treating ulcers in patients who have a history of gastric
bypass surgery?
- does taking the open versus intact medication decrease the number of procedures and
complications from untreated ulcers?
Participants with ulcers will be instructed to take acid-blocking medications (called
proton-pump inhibitors) either by opening the capsule and taking only the contents or by
taking the capsule whole. These medications are the gold standard for treatment of stomach
ulcers. Participants will be asked to undergo an upper endoscopy (EGD) every 3 months to
monitor the healing of the ulcers.
Researchers will compare how quickly the ulcers heal depending on which way the medications
are taken (opened up or as a whole).