Overview

ODSH + ICE Chemotherapy in Pediatric Solid Tumors

Status:
Terminated
Trial end date:
2017-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study will be with pediatric patients who have refractory/recurrent solid tumors. They will receive standard chemotherapy (ICE) and we are investigating if the addition of a new drug, ODSH, will help to increase the time of their platelet recovery after ICE chemotherapy.The purpose of this study is to evaluate the safety and tolerability of ODSH in pediatric patients receiving "ICE" chemotherapy.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
New York Medical College
Treatments:
Heparin
Criteria
Inclusion Criteria:

- Recurrent or refractory solid tumors. This may include, but is not limited to,
osteosarcoma, chondrosarcoma, Ewing's sarcoma, Wilm's Tumor, medulloblastoma,
neuroblastoma, hepatoblastoma, rhabdomyosarcoma, retinoblastoma, and primitive
neuroectodermal tumors. Histologic proof malignancy must have been available at the
time of initial diagnosis.

- Age: 1-21

- Patients must have received standard first-line chemotherapy or other appropriate
standard first line therapy for their malignancy.

- Patients must have radiologic or histologic evidence of recurrence

- Patients must have fully recovered from the toxic effects of the prior chemotherapy
and must have an ANC >1000/μL and a platelet count >100,000/μL

- Performance status > 60 from Lansky (age 1 to 16) or Karnofsky (age > 16)

- Adequate hepatic and renal function (AST, ALT, bilirubin and creatinine < 2.5 x upper
normal limit).

- Parent or guardian able to provide informed consent and have signed an approved
consent form that conforms to federal and institutional guidelines.

Exclusion Criteria:

- Patients who, in the investigator's opinion, have extensive bone marrow involvement
with tumor

- Presence of significant active infection or uncontrolled bleeding

- Renal insufficiency, which, in the opinion of the investigator, might adversely affect
schedule and dose of therapy ICE chemotherapy. patients with creatinine levels ≥2
mg/dl are not eligible

- Pre-existing liver disease , other than liver metastasis

- Use of recreational drugs within the prior month

- Known history of positive hepatitis B surface antigens or HCV antibodies

- Known history of positive test for HIV antibodies

- Patients receiving any form of anticoagulant therapy

- Presence of a known bleeding disorder or coagulation abnormality

- Treatment with any other investigational agent, or participation in another clinical
trial within 28 days prior to study entry

- Pregnant or breast-feeding patients

- Patient with childbearing potential not using adequate contraception

- Hemorrhage risk that requires maintenance of platelet counts at 50,000 or higher.

- Psychiatric or neurologic conditions that could compromise patient safety or
compliance, or interfere with the ability of the patient or family to give proper
informed consent.