OCP vs Metformin on Ovarian Stromal Blood Flow in PCOS

• Status: Completed
• Trial end date: 2018-03-15
• Target enrollment: 0
• Participant gender: Female

Summary

This study is undertaken to compare the effects of treatment with commonly used OCP containing ethinylestradiol-cyproterone acetate and metformin in women with PCOS. Special attention will be paid to changes in ovarian stromal blood flow by using Color Doppler and they will be correlated with changes in hormonal parameters post-treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: S.C.B. Medical College and Hospital
• Treatments: Cyproterone; Cyproterone Acetate; Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Ethinyl Estradiol; Metformin; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Women diagnosed with PCOS according to the Rotterdam criteria

Exclusion Criteria:

• Current or previous use of oral contraceptives, glucocorticoids, antiandrogens, ovulation induction agents, antidiabetic and anti-obesity drugs or other hormonal drugs.

• Medical or surgical treatment of PCOS during the previous 3 months

• Presence of other endocrinopathies; except treated hypothyroidism on stable replacement doses of thyroid hormone

• Pregnancy, breastfeeding or desire for pregnancy during study interval (6 months)

• Inability to understand the proposal of the study precluding effective informed consent