Nutrition and Exercise for Sarcopenia

• Status: Completed
• Trial end date: 2016-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators' general hypothesis is that nutritional factors, including protein/energy malnutrition and/or an impaired response of muscle to nutrition, and inactivity play significant roles in developing sarcopenia, the involuntary loss of muscle mass and function with age. Therefore, age-specific prolonged interventions including nutritional manipulations and/or exercise may help to reduce, stabilize, or even reverse sarcopenia.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Medical Branch, Galveston
• Collaborator: National Institute on Aging (NIA)

Criteria

Inclusion Criteria:

1. age 65-85 yrs

2. ability to sign consent form (score >25 on the 30 item Mini Mental State Examination, MMSE)

3. stable body weight for at least 1 year (verified via medical records).

Exclusion Criteria:

1. physical dependence or frailty (impairment in any of the Activities of Daily Living (ADL), history of falls (≥2/year) or significant weight loss in the past year)

2. exercise training (≥2 weekly sessions of moderate-to-high intensity aerobic or resistance exercise)

3. significant heart, liver, kidney, blood or respiratory disease

4. peripheral vascular disease

5. diabetes or other untreated endocrine disease

6. active cancer

7. recent (within 6 months) treatment with anabolic steroids, or corticosteroids

8. alcohol or drug abuse

9. tobacco use (smoking or chewing, verified via medical records)

10. depression (>5 on the 15-item Geriatric Depression Scale (GDS))

11. malnutrition (BMI <20 kg/m2; hypoalbuminemia or hypotransferrenemia; protein intake<0.66 g/kg/day at run-in)

12. obesity (BMI>30 kg/m2).