Novel Neuroimage Study in Tauopathies With Parkinsonism
Status:
Completed
Trial end date:
2019-07-31
Target enrollment:
Participant gender:
Summary
The aims of this study are: 18F-THK5351 PET(Positron Emission Tomography) can defect the tau
burden in PSP(Progressive Supranuclear Palsy) and CBS (Corticobasal syndrome)correlating with
the known NFT(neurofibrillary tangles) topology of those diseases, 18F-THK5351 PET will
differentiate subjects with suspected tauopathy due to PSP and CBS from subjects with
suspected synucleinopathy due to idiopathic PD(Parkinson's disease). The distribution of
PHF(paired helical filament) tau burden will correlate with specific motor and cognitive
features of PSP and CBS; and regional PHF tau burden will be associated with cortical
thinning. Together, these efforts will establish the potential for developing 18F-THK5351 PET
imaging as a biomarker and diagnostic tool for the parkinsonian tauopathies.