Vasovagal syncope (VVS, simple faint) is the most common cause of transient loss of
consciousness and represents the acute episodic form of orthostatic intolerance (OI).
Postural tachycardia syndrome (POTS) is the common chronic form of OI. Both are defined by
debilitating symptoms and signs while upright relieved by recumbency. Northera should
therefore improve both sympathetic splanchnic arterial vasoconstriction and sympathetic
splanchnic venoconstriction in POTS and VVS, and may represent an ideal drug to improve the
orthostatic response in POTS and VVS.