Normal Versus Dual Wave Insulin Bolus for High-protein Food

• Status: Completed
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients receive a standardized high-protein test meal at breakfast time. Insulin is given as bolus (normal or dual-wave (normal plus square) and basal rate using an insulin pump. The 3h post-meal glucose excursions will be recorded by self-blood glucose measurements (SMBG) (every 1 hour) and continuous glucose monitoring system (CGMS). The intervention is taking part under in-patient clinical conditions.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Warsaw
• Treatments: Insulin; Insulin Aspart; Insulin degludec, insulin aspart drug combination; Insulin glulisine; Insulin Lispro; Insulin, Globin Zinc; Insulin, Long-Acting

Criteria

Inclusion Criteria:

• duration of type 1 diabetes longer than 12 months

• insulin pump therapy longer than 3 months

• written informed consent by patients and parents

• patients must be willing to wear a glucose sensor for two days

• insulin requirement more than 0,5 units/kg/day

Exclusion Criteria:

• concomitant dietary restrictions (e.g. celiac disease or food allergy)

• diabetes related complications (e.g. nephropathy)

• any disease judged by the investigator to affect the trial

• withdrawal of consent to participate in the study