Norepinephrine vs Phenylephrine During General Anesthesia
Status:
Recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
50 million patients undergo surgery each year in the United States. Postoperative mortality
is considered the third leading cause of death worldwide. Hypotension during surgery have
been linked to increased postoperative morbidity and mortality. Episodes of hypotension
during surgery are associated with an increased risk of acute kidney injury, stroke, cardiac
events and death. Treating or preventing hypotension during general anesthesia and major
surgery was found to improve outcomes. At this time, it is unclear what is the best
vasopressor to maintain blood pressure during surgery under general anesthesia. With this
pilot pragmatic trial, the investigators will explore the impact of norepinephrine (NE) or
phenylephrine (PE) on post-operative events in patients undergoing major surgery with general
anesthesia and needing vasopressors infusion to maintain their systemic arterial pressure.