Norepinephrine and Phenylephrine, Which Better for Elderly?

• Status: Unknown status
• Trial end date: 2020-01-30
• Target enrollment: 0
• Participant gender: All

Summary

this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative hypotension, and to find the safest and most effective vasopressor for elderly.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Second Affiliated Hospital of Dalian Medical University
• Treatments: Norepinephrine; Oxymetazoline; Phenylephrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• radical resection of colorectal or gastric cancers,

• age over 65 years old,

• surgical time longer than 2hours,

• the American Society of Anesthesiologists(ASA) classification of II or III

Exclusion Criteria:

• history of severe cardiovascular diseases,

• history of severe liver and kidney diseases,

• evidence of arrhythmia on EKG,

• use of positive end-expiratory pressure (PEEP) during mechanical ventilation;

• conditions with relative contraindication for arterial catheterization