Overview

Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock

Status:
Completed

Trial end date:
2019-01-06

Target enrollment:
0

Participant gender:
All

Summary

Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial blood pressure in refractory septic shock and to decrease exposure to norepinephrine. The aim of the work is to compare the effect of norepinephrine alone and Norepinephrine/vasopressin combination on hemodynamics and tissue perfusion in septic shock patients.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Ain Shams University

Treatments:

Arginine Vasopressin
Norepinephrine
Vasopressins

Criteria

Inclusion Criteria:

- Age > 18 years of both sex

Exclusion Criteria

- Patients with renal impairment (Creatinine>2mg/dl)

- Sever Heart Disease (ischemic/valvular)

- Peripheral vascular disease (e.g. Raynaud's phenomenon)