The fundamental hypothesis of this project is that real-time intracardiac pressures can be
monitored and quantified noninvasively in humans using a novel contrast-enhanced ultrasound
technique called subharmonic-aided pressure estimation (SHAPE).This study will use contrast
echocardiography to assess the accuracy of SHAPE compared to simultaneously acquired
intracardiac pressures measured invasively during cardiac catheterization. This study is
designed to verify that contrast echocardiography using the SHAPE method, already proven in a
canine model and tested in a human pilot study can be used as a surrogate for cardiac
catheterization with sufficient accuracy to allow clinical applicability in humans.
Phase:
Phase 2
Details
Lead Sponsor:
Thomas Jefferson University
Collaborators:
American Heart Association Lantheus Medical Imaging