Overview

Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

Status:
Completed
Trial end date:
2007-06-01
Target enrollment:
0
Participant gender:
Male
Summary
to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation
Phase:
Phase 3
Details
Lead Sponsor:
Baqiyatallah Medical Sciences University
Criteria
Inclusion Criteria:

- a history of previous exposure to sulfur mustard

- worsening dyspnea during the last 10 days

- respiratory rate >25/min

- arterial pH<7.35

- PaCO2 of >50 mmHg

- PaO2 of <50 mmHg

Exclusion Criteria:

- recent pneumothorax (<1 month)

- severe respiratory failure or hemodynamic instability with forthcoming intubation

- FIO2 of <0.4

- impaired consciousness or absence of patient cooperation

- facial lesions precluding NIV