Non-myeloablative Allogeneic Transplantation for the Treatment of Multiple Myeloma
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
Mixed chimerism transplantation is an approach to allogeneic transplants that attempts to
decrease regimen-related toxicity by using non-myeloablative preparatory regimens; establish
mixed chimerism using low dose total body irradiation along with immunosuppression using
cyclosporine and mycophenolate mofetil; suppress graft-vs-host and host-vs-graft reactions to
allow a mixed chimeric state to be established, encourage tolerance and prevent graft-vs-host
disease (GvHD) during the mixed chimerism period and use donor lymphocyte infusions to
convert the patient to a full chimera while developing a graft-vs-tumor effect.