Overview

Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone

Status:
Not yet recruiting

Trial end date:
2023-06-01

Target enrollment:
0

Participant gender:
Female

Summary

This study aimed to investigate Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone in female patients. Methods: A total of 60 patients were randomly divided into 3 groups, with 20 patients in each group. Sufentanil(0.1μg/kg), Hydromorphone(20μg/kg), or Oxycodone(60μg/kg) was administered before anesthesia induction. Bispectral Index (BIS), Respiratory rate(RR), other non-analgesic effects at Tb (entering room), T0 (drug administration), T1 (2min), T2 (4min), T3(6min), T4(8min), T5(10min), T6(20min) were recorded.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Peking University People's Hospital

Treatments:

Hydromorphone
Oxycodone
Sufentanil

Criteria

Inclusion Criteria:

- American Society of Anesthesiologists GradeⅠ-II;

- Patients undergo low-risk elective surgery for benign diseases (including laparoscopic
ovarian cyst removal, laparoscopic tubal ligation, laparoscopic tubal drainage, breast
operation, thyroid operation, etc) ;

- Aged 18-45 years;

- Body Mass Index 18-25kg/m2, weight 40-65 kilograms;

- Agreed to participate in the research

Exclusion Criteria:

- Difficult airway;

- upper respiratory tract infection within 2 weeks;

- history of allergy or long-term use of propofol and opioids;

- self-rating anxiety scale before operation indicates anxiety;

- pregnancy or lactation.