Background:
A person s white blood cells can be modified in a lab to recognize certain changes in their
tumor. Many of these cells are collected from the person, modified, then given back to the
person. This may help treat some cancers.
Objective:
To learn if a person s white blood cells modified with T-cell receptors can cause solid
tumors to shrink.
Eligibility:
People ages 18-70 who have cancer of the gastrointestinal tract, genitourinary tract, ovary,
breast, or lung that has spread, or who have glioblastoma.
Design:
Participants will be screened and have their cells prepared for treatment in another
protocol.
Participants will be hospitalized one week before treatment. They will stay approximately 3 -
4 weeks after treatment.
Participants will get the modified white blood cells and chemotherapy through an IV catheter,
which is a small plastic tube inserted in a vein.
Participants will take drugs by mouth to prevent infection. They will receive filgrastim as a
shot or injection under the skin.
Participants will have tests before, during, and after treatment:
Heart, blood, and urine tests
Chest X-ray
Physical exam
Scans: They will lie in a machine that takes pictures of the body.
Possible apheresis: The participant s blood is removed through a needle in an arm. The blood
goes through a machine that removes the white blood cells. The rest of the blood is returned
through a needle in the other arm.
Participants will have visits about 6 and 12 weeks after treatment. If they are responding to
treatment, they will then have visits every 3-6 months for 3 years. Then they will join
another study and be followed about 12 more years.