Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)
Status:
Completed
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
BACKGROUND Migraine headaches account for 8-18% of all headaches seen in pediatric emergency
rooms. Standard treatment includes IV pain medications, anti-emetics, and IV fluids. Nitrous
oxide has analgesic properties similar to those of opioids and is easy to administer. It has
been shown in two small studies to be effective in treating migraine headaches.
RESEARCH QUESTION Does nitrous oxide act as a safe, less invasive, and effective treatment of
acute migraine headaches in children and adolescents presenting to an Emergency Department?
DESIGN This is a prospective non-randomized self-controlled study. Repeated measures will be
taken to examine change in pain scores before and after nitrous oxide treatment.
METHODS Each participant will be given nitrous oxide until he/she reports a pain score of
zero or up to fifteen minutes. Study subjects will be asked to rate their pain on a scale of
0-10 before the treatment and after the treatment at multiple time-points.