Nitrite in Hypertrophic Cardiomyopathy (HCM) Study
Status:
Unknown status
Trial end date:
2019-01-01
Target enrollment:
Participant gender:
Summary
Inorganic nitrate, which is found at high levels in green leafy vegetables, is reduced to
nitrite by bacteria in the mouth, swallowed, and absorbed in the stomach into the blood.
Studies have shown that increasing the blood levels of nitrite improves the way that muscles
use oxygen and energy during exercise, and potentially blood flow.
Some people (~1 in 500) suffer from a type of genetic heart condition known as hypertrophic
cardiomyopathy (HCM). This condition means that the muscle in the heart does not use energy
well and becomes larger than average, meaning that they have to tap into the heart's 'energy
reserves'. It is not known if nitrite has the same beneficial effects on heart muscle as on
other muscles in the body. Our study will explore the mechanism by which nitrite may improve
the function and energy status of the heart in HCM.
Phase:
Phase 1
Details
Lead Sponsor:
University of East Anglia
Collaborators:
British Medical Research Council Norfolk and Norwich University Hospitals NHS Foundation Trust