Nitrite Supplementation for Improving Physiological Function in Older Adults
Status:
Completed
Trial end date:
2019-05-01
Target enrollment:
Participant gender:
Summary
Nitric oxide (NO) is an essential molecule in the body that decreases with aging and causes
reductions in vascular, movement ("motor") and cognitive functions. This study will determine
if daily oral supplementation (3 months) with a compound that increases NO in the body, i.e.,
sodium nitrite, improves vascular, motor and cognitive function in older adults. The project
also seeks to provide insight into the biological reasons (mechanisms) by which
supplementation with sodium nitrite improves physiological function in older adults. Overall,
this research will provide scientific evidence supporting the use of sodium nitrite for
preserving physiological function and preventing clinical disease and disability with aging.