This a single center, randomized controlled trial to evaluate safety & efficacy of topical
nitric oxide releasing sinus irrigation (NOSi) as compared to budesonide-Saline (Control) in
the management of biofilm-associated recalcitrant chronic rhinosinusitis (RCRS). It is
hypothesized that a daily treatment of NOSi over a 6-week period will be safe and effective
at reducing clinical symptoms associated with RCRS.