Overview

Nitric Oxide During Cardiopulmonary Bypass in Adult Surgery

Status:
Recruiting

Trial end date:
2023-05-01

Target enrollment:
0

Participant gender:
All

Summary

Inhaled nitric oxide is a widely accepted standard of care for pulmonary hypertension, and has been studied in the context of cardiac surgery. CPB during cardiac surgery induces systemic inflammatory response and ischemic-reperfusion injury of many organs. Nitric oxide added to the bypass circuit may have anti-inflammatory effect and has shown the potential to ameliorate organs' injury . There is evidence that the delivery of nitric oxide to the oxygenator gas flow during pediatric CPB is accompanied by a reduction in myocardial injury markers' levels in the postoperative period. In adults, NO supply to the CPB circuit during CABG exerted a cardioprotective effect and was associated with a lower level of inotropic support and cardio-specific blood markers . To our knowledge, this is the first trial to assess whether artificial nitric oxide supplementation to the CPB-system reduces the incidence of hypoxemia after cardiac surgery.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Rabin Medical Center

Treatments:

Nitric Oxide

Criteria

Inclusion Criteria:

1. Patients undergoing elective CABG surgeries with CPB at Rabin Medical Center Beilinson
hospital.

2. Patients undergoing valve replacement/repair surgeries with CPB at Rabin Medical
Center Beilinson hospital.

Exclusion Criteria:

1. Patients requiring ECMO use preoperatively.

2. Patients requiring IABP use preoperatively.

3. Patients experiencing preoperative shock (defined as the need for ionotropic and/or
vasopressor support).

4. Patients after solid organ transplant surgery.

5. Patients with LVAD.

6. Patients with ESRD requiring dialysis preoperatively.

7. Patients with a language barrier.

8. Patients unable to give informed consent.

9. Patients with heparin induced thrombocytopenia.