Nitric Oxide During Cardiopulmonary Bypass in Adult Surgery
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
Inhaled nitric oxide is a widely accepted standard of care for pulmonary hypertension, and
has been studied in the context of cardiac surgery. CPB during cardiac surgery induces
systemic inflammatory response and ischemic-reperfusion injury of many organs. Nitric oxide
added to the bypass circuit may have anti-inflammatory effect and has shown the potential to
ameliorate organs' injury .
There is evidence that the delivery of nitric oxide to the oxygenator gas flow during
pediatric CPB is accompanied by a reduction in myocardial injury markers' levels in the
postoperative period. In adults, NO supply to the CPB circuit during CABG exerted a
cardioprotective effect and was associated with a lower level of inotropic support and
cardio-specific blood markers .
To our knowledge, this is the first trial to assess whether artificial nitric oxide
supplementation to the CPB-system reduces the incidence of hypoxemia after cardiac surgery.