Nitric Oxide Donors for Treatment of Isolated Oligohydramnios
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
Objective: To assess the influence of maternal isosorbide mononitrate (IMN) vaginal
supplementation in improving liquor volume in women with isolated oligohydramnios.
Study Design: Prospective randomized interventional study. Materials and Methods: 100 women
with singleton pregnancy about 28-36 weeks, with isolated oligohydramnios [amniotic fluid
index (AFI) < 5] were enrolled in the study. Before the proposed intervention, the antenatal
risk factors were studied. Patients received 20 mg isosorbide mononitrate (IMN) vaginally.
Patient were followed after 24 hours then weekly. The treatment was continued till the liquor
improved significantly or until delivery. Outcome measures; mean increase in liquor,
intervention delivery interval, and neonatal outcome were studied.