Nimotuzumab in Combination With Chemoradiation for Local Advanced Esophageal Squamous Cell Carcinoma
Status:
Unknown status
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Nimotuzumab is a humanized monoclonal antibody against epidermal growth factor receptor
(EGFR). Clinical trials are ongoing globally to evaluate Nimotuzumab in different
indications. Nimotuzumab has been approved to treat squamous cell carcinoma of head and neck
(SCCHN), glioma and nasopharyngeal carcinoma in different countries. The clinical phase I
study of the combination of Nimotuzumab administered concurrently with chemo-irradiation in
patients with local advanced esophageal squamous cell carcinoma (LAFSCC) has shown the safety
and the potential efficacy of Nimotuzumab. The concurrent trial is a clinical phase II trial
designed to assess the efficacy of the combination of Nimotuzumab administered concurrently
with chemo-radiotherapy in patients with LAFSCC, and to further investigate its side-effect
and toxicity.