Overview

Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium

Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
0
Participant gender:
All
Summary
Thiazide diuretics will be more effective in lowering urine calcium excretion if taken at night as compared to the daytime. It will therefore be more effective in reducing kidney stone recurrence in nephrolithiasis patients with elevated urine calcium who are known to have increased risk of kidney stones at night time.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
VA New York Harbor Healthcare System
Treatments:
Calcium, Dietary
Chlorthalidone
Diuretics
Hydrochlorothiazide
Sodium Chloride Symporter Inhibitors
Criteria
Inclusion Criteria:

- Patients with recurrent calcium kidney stones (at least 2 episodes) and either a
higher urine calcium excretion (urine Ca >200 mg/d or > 4 mg/kg body weight) or,

- In patients who currently take a thiazide diuretic, a history of elevated urine
calcium prior to medication use;

- Also capable of signing consent and doing 24-hour urine collections repeatedly.

Exclusion Criteria:

- Patients with primary hyperparathyroidism, renal tubular acidosis, chronic kidney
disease (serum creatinine > 1.5 mg/dl), inflammatory bowel disease, gout,

- Patients taking thiazides with a history of hypertension,

- Patients with baseline systolic blood pressure less than 110mmHg