Nicotine Patch, Blood Flow and Oxidative Stress Study

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will address the hypothesis that nicotine, like cigarette smoking acting as a pro-oxidant may have adverse effects on arterial function.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pennsylvania
• Collaborator: National Institutes of Health (NIH)
• Treatments: Nicotine

Criteria

Inclusion Criteria:

• Healthy individuals

• Nonsmokers who have never smoked

• Normal medical history

• Normal physical examination

• Normal laboratory data

• Negative urinary pregnancy test for females

Exclusion Criteria:

• Previous CVD

• Chronic medication use

• History alcoholism

• History of smoking

• Current pregnancy

• Subjects, who have less than or equal to 60% platelet aggregation in response to arachidonic acid will also be excluded.