Nicotine, Non-Smokers With and Without ADHD, and Genetics Study
Status:
Completed
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
The overall goal of the proposed research is to evaluate the behavioral and genetic
mechanisms of smoking risk in non-smoking young adults (aged 18-25 years of age) with and
without ADHD using a novel laboratory-based model of intranasal nicotine administration.
Study Hypotheses:
1. that nicotine will produce greater positive and fewer negative/aversive subjective
effects in individuals with ADHD. The study team also hypothesizes that nicotine will
improve performance to a greater degree in those with ADHD.
2. that individuals in the ADHD group will exhibit an increase in choices for nicotine vs.
placebo in both conditions (i.e., main effect) and that this effect will be more
pronounced in the High Demand vs. Low Demand conditions (i.e. Group x Condition
interaction). Also that greater performance enhancing effects of nicotine will be
associated with greater nicotine choice during the high demand cognitive condition.
3. that the main effects of ADHD status on nicotine reinforcement will be heightened in the
presence of certain genotypes. Also that the main effects of ADHD status on nicotine
reinforcement will be heightened in the presence of certain genotypes. Finally that
exposure to nicotine will alter epigenetic patterns in DNA