Overview

Newly-diagnosed Pediatric T-cell ALL Protocol

Status:
RECRUITING
Trial end date:
2031-06-01
Target enrollment:
Participant gender:
Summary
This is a prospective, multicenter study conducted within the Chinese Children's Cancer Group (CCCG). The study aims to evaluate whether the addition of three novel agents, dasatinib, venetoclax and homoharringtonine, can improve the minimal residual disease (MRD)-negative remission rate, enhance event-free survival (EFS), and reduce the cumulative incidence of relapse (CIR) in pediatric patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL).
Phase:
PHASE2
Details
Lead Sponsor:
Institute of Hematology & Blood Diseases Hospital, China
Treatments:
Asparaginase
Cytarabine
Dasatinib
Daunorubicin
Dexamethasone
Homoharringtonine
Methotrexate
venetoclax
Vincristine