New Medication Treatment for Stimulant Dependence

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Virginia
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Central Nervous System Stimulants; Ondansetron

Criteria

Inclusion Criteria:

• Males and females who have given written informed consent.

• Ages 18 years and above and, must weigh at least 40 Kg and no more than 140 Kg.

• Good physical health as determined by a complete physical examination, an EKG within normal limits, and laboratory screening tests within acceptable parameters.

• Current DSM-IV diagnosis of cocaine dependence.

• At least one positive urine drug screen for cocaine at screen or baseline prior to randomization.

• The pregnancy test for females at intake must be negative.

• Literacy in English and ability to read, understand, and complete the ratings scales and questionnaires accurately, follow instructions, and make use of the behavioral treatments.

• Answered an advertisement in the newspaper/radio/television, and expressing a wish to stop using cocaine.

• Willing to participate in behavioral treatments for cocaine dependence.

Exclusion Criteria:

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