Neurovascular Complications and White Matter Damage in Acquired Anemias
Status:
Not yet recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
This is an observational trial, with an interventional arm, in patients with moderate to
severe anemia and control subjects. The main purpose of this study is to understand whether
normal brain blood flow, oxygen extraction reserve, white matter volumes, and brain
functional connectivity are affected by acquired anemia. We will perform baseline MRI
monitoring for all subjects. Subjects with confirmed iron defiency will be offered
intravenous iron therapy. Repeat MRI will be performed twice following iron replacement
therapy. All eligible subjects will be asked to provide informed consent before participating
in the study.