Overview

Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
Open-label, single-arm, single center pilot study to assess safety and feasibility of administering dexamethasone intrathecally and simvastatin orally during axicabtagene ciloleucel (axi-cel) treatment. Feasibility will be measured by the proportion of patients completing two-thirds (2/3) of their assigned treatments. The study will be deemed feasible if 2/3 or more of the patients complete 2/3 or more of their allocated treatments.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Masonic Cancer Center, University of Minnesota
Treatments:
Dexamethasone
Simvastatin
Criteria
Inclusion Criteria:

- 18- 80 years of age

- One of the following histologies:

- Diffuse large B-cell lymphoma (DLBCL) not otherwise specified, or

- Primary mediastinal B-cell lymphoma, or

- High grade B-cell lymphoma, or

- DLBCL arising from follicular lymphoma

- Disease status:

- Chemotherapy refractory disease after ≥2 lines of chemotherapy, or

- Relapsed with no remission after ≥1 lines of salvage chemotherapy, or

- Relapsed following autologous hematopoeitic stem cell transplantation (and failed
at least 2 prior lines of therapy including high dose chemotherapy). If salvage
therapy is given post auto HCT, the subject must have no complete response, or
relapse after the last line of therapy

- Performance Status

- ECOG performance status 0-2

- Adequate organ function defined as:

- Renal function defined as:

- eGFR ≥ 30 mL/min/1.73 m^2

- Liver function defined as:

- ALT and AST ≤ 5 times the ULN for age (unless due to disease)

- Bilirubin ≤ 2.0 mg/dl with the exception of patients with Gilbert syndrome;
may be included if their total bilirubin is ≤ 3.0 x ULN and direct bilirubin
≤ 1.5 x ULN

- Hemodynamically stable and LVEF ≥ 40% confirmed by echocardiogram or MUGA

- Women of childbearing potential and men with partners of child-bearing potential must
agree to use of contraception for the duration of treatment as outlined in axi-cel
protocol.

- Able to provide written voluntary consent (or LAR consent for adults with diminished
capacity) prior to the performance of any research related tests or procedures

- Availability of a certified practitioner to perform the lumbar punctures

Exclusion Criteria:

- Allergies, or intolerance to simvastatin or dexamethasone

- Already receiving a statin drug for hypercholesterolemia and unwilling to change
medication to 40 mg/day of simvastatin

- Active uncontrolled CNS lymphoma. Patients with history of CNS lymphoma who have been
adequately treated are eligible

- Presence of Grade 2 to 4 acute or extensive chronic graft-versus-host disease (GVHD).

- Uncontrolled active hepatitis B or hepatitis C

- Active HIV infection

- Uncontrolled acute life threatening bacterial, viral or fungal infection

- Unstable angina and/or myocardial infarction

- Risk factors that preclude a safe lumbar puncture (high intracranial pressure,
bleeding diathesis that cannot be reversed or corrected, need for uninterrupted
anticoagulation, platelets < 50K that cannot be corrected with transfusional support

- Pregnant or breastfeeding as agents used in this study are Pregnancy Category C
(dexamethasone) and X (simvastatin). Females of childbearing potential must have a
negative pregnancy test (serum or urine) within 7 days of study registration.