Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10

• Status: Completed
• Trial end date: 2021-10-30
• Target enrollment: 0
• Participant gender: Male

Summary

The compound ACTH4-10Pro8-Gly9-Pro10 is a synthetic analog molecule of an adrenocorticotropic hormone (ACTH) short fragment. That is free from hormonal effects and has neuromodulatory effects. We investigate the neuroprotective effects of ACTH4-10Pro8-Gly9-Pro10 can lessen neurotoxicity against ketamine in neonatal rats by looking at BDNF expression in the cortex and hippocampus tissue as well as BDNF blood levels.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitas Sumatera Utara
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Rattus norvegicus rats

• Male, seven days old, weighing 15-20 grams

• Spraque-Dawley strain, obtained from the Experimental Animal Care Unit

Exclusion Criteria:

• Animals that behave aggressively in observation by attacking other groups