Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy

• Status: Completed
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will be conducted to evaluate the effect of vitamin B12 and vitamin B6 in delaying the onset and reducing the incidence and severity of Vincristine Induced Peripheral Neuropathy (VIPN) in Acute Lymphoblastic Leukemia (ALL) patient.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
• Treatments: Hydroxocobalamin; Neuroprotective Agents; Pyridoxal; Pyridoxine; Vincristine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

1. All patients, 18 years of age or older with newly diagnosed ALL going to start induction chemotherapy with Vincristine

2. Patients with good performance status (ECOG 0- 3)

3. Patients with no preexisting peripheral neuropathy

4. Patients with grade 0 neuropathy on admission

5. Patients with normal renal function (Serum creatinine <1.5 mg/dl)

6. Patients agree to participate in the study signing an informed written consent

Exclusion Criteria:

1. Pregnant women and nursing mothers

2. Patients with clinical neuropathy due to diabetes mellitus or other causes

3. Patients with head neck tumors

4. Patients taking anticonvulsants, antidepressants, opioids, vitamin E and other neuropathic pain medication agents