Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX)
Status:
Recruiting
Trial end date:
2022-12-23
Target enrollment:
Participant gender:
Summary
The prevention of the occurrence of respiratory events is a constant concern in pediatric
anesthesia, as these represent the main cause of the anesthesic mortality. These events occur
partly during induction of anesthesia and are all the more frequent as the child is young.
The French recommendations do not propose the use of neuromuscular-blocking agents in
pediatric anesthesia. This recommendation is controversial In a recently published study, it
has been shown that the use of neuromuscular blocking agents during induction in children
under 2 years improves intubating conditions and reduces the incidence of hemodynamic and
respiratory events. This monocentric study, centered on intubating conditions, does not allow
to conclude on the influence of muscle relaxants on reduction of the respiratory morbidity.
The objective of study is to demonstrate that, in children under 2 years, changing the
anesthesia protocol can reduce the incidence and severity of episodes of hypoxemia associated
with respiratory events occurring during induction