Neuromuscular Blockade on Shoulder Pain of Elderly
Status:
Completed
Trial end date:
2020-10-22
Target enrollment:
Participant gender:
Summary
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the
abdomen to allow the surgeon more space to work during abdominal surgery. Shoulder pain is a
common complaint from patients who have had abdominal surgery and the pain is thought to be
related to the use of IP.
In addition to anesthesia (which keeps you asleep during surgery), the current standard
practice is to block the nerve-muscle junction with a type of drug called neuromuscular
blockade (NMB) which paralyzes the abdominal muscles. This means that a lower level of
insufflation pressure is needed by the surgeon.
To reverse the effects of NMB after surgery, a drug called neostigmine is given.
The goal of this clinical research study is to compare the use of standard-of-care moderate
NMB and neostigmine to the use of deep NMB and a drug called Sugammadex when given to elderly
patients (patients who are 65 years of age or older) who are scheduled to have robotic
abdominal surgery. "Deep" and "moderate" in this study refers to the dose or strength of the
NMB given.
This is an investigational study. Sugammadex and neostigmine are FDA approved and
commercially available for the reversal of NMB. It is considered investigational to compare
Sugammadex and neostigmine to learn if the use of one or the other in elderly patients can
reduce the level of shoulder pain after surgery.
Up to 100 participants will be enrolled in this study. All will take part at MD Anderson.