Neuromuscular Blockade for Post-Cardiac Arrest Care

• Status: Completed
• Trial end date: 2019-05-29
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this study is to evaluate if neuromuscular blockade improves lactate clearance (and preliminary secondary clinical outcome measures) as compared to usual care in post-cardiac arrest patients undergoing targeted temperature management.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Collaborators: Beaumont Hospital; Brigham and Women's Hospital; University of Alabama at Birmingham; University of Pittsburgh; University of Pittsburgh Medical Center
• Treatments: Rocuronium

Criteria

Inclusion Criteria:

• Adult (≥ 18 years)

• Cardiac arrest with sustained return of spontaneous circulation (ROSC)

• Comatose (i.e., not following commands) following ROSC

• Undergoing targeted temperature management (TTM)

• Time of enrollment ≤ 6 hours from initiation of targeted temperature management

• Serum Lactate ≥2

Exclusion Criteria:

• Pre-existing dementia, severe brain injury, or dependence on others for activities of daily living (i.e. a modified Rankin scale (mRS) score of 4 or higher)

• Traumatic etiology of the cardiac arrest

• Protected population (pregnant, prisoner)