Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
The current study is being conducted in patients with major depression. The study aims to 1)
investigate the combined effects of selective serotonin reuptake inhibitor (SSRI) and
bupropion compared to SSRI alone on the improvements of depressive symptoms, fatigue,
hypersomnia, and neurocognitive functions, 2) observe structural/functional/chemical changes
using magnetic resonance imaging (MRI), 3) and examine a relationship between the
improvements of depressive symptoms, fatigue, and hypersomnia and the neural changes.