Overview

Neuroimaging Studies of Dexmedetomidine- and Ketamine-Induced Analgesia

Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
0
Participant gender:
All
Summary
Neuroimaging data will be collected for patients that are given low doses of dexmedetomidine and ketamine in order to understand their analgesic effects.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Massachusetts General Hospital
Treatments:
Dexmedetomidine
Ketamine
Criteria
Inclusion Criteria:

- Between the ages of 18 to 45

- Normal body weight and habitus, BMI ≤ 30

- Non-smoker

- American Society of Anesthesiologists (ASA) physical status classification P1

- Active health insurance coverage

Exclusion Criteria:

- Cardiovascular: myocardial infarction, coronary artery disease, peripheral vascular
disease, arrhythmia, congestive heart failure, valvular disease, hypertension

- Respiratory: bronchitis, chronic obstructive pulmonary disease, smoking, shortness of
breath

- Hepatic: hepatitis, jaundice, ascites

- Neurologic: seizure, stroke, positive neurologic findings on neurologic examination,
multiple sclerosis, Meniere's disease, Parkinson's disease, neuropathy, peripheral
stenosis

- Gastrointestinal: esophageal reflux, hiatal hernia, ulcer

- Endocrine: diabetes, thyroid disease

- Renal: acute or chronic severe renal insufficiency

- Hematologic: blood dyscrasias, anemia, coagulopathies, on anticoagulant therapy

- Musculoskeletal: prior surgery or trauma to head neck or face, arthritis, personal or
family history of malignant hyperthermia

- Psychiatric: history or treatment for an active psychiatric problem, depression

- Reproductive: pregnancy, breast-feeding

- Medications: regular use of prescription and non-prescription medications expected to
affect CNS function, St. John's Wort

- Allergies: labetalol, ondansetron, glycopyrrolate, ketamine, zofran, haloperidol,
phenylephrine

- Dermatologic: ulcerative skin conditions or other dermatologic conditions which could
interfere with blood pressure cuff placement.

- MRI reasons for exclusion: History of head trauma, surgical aneurysm clips, cardiac
pacemaker, prosthetic heart valve, neurostimulator, implanted pumps, cochlear
implants, metal rods, plates, or screws, intrauterine device, hearing aid, dentures,
metal injury to eyes, metallic tattoos anywhere on the body or near the eye.