Neuroimaging Predictors of Antidepressant Treatment Outcome
Status:
Withdrawn
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Current medical therapies for depression take weeks to achieve full efficacy, and are
ineffective in many patients or cause intolerable side effects, emphasizing the need for a
deeper understanding of depression and its treatment. Identifying early brain biomarkers of
treatments responses seems necessary to improve antidepressant treatment outcome. In this
study we aim to detect early brain responses to a fast acting antidepressant-like treatment
administered intravenously during a Real-Time Neurofeedback functional magnetic resonance
imaging (MRI) Task to predict antidepressant treatment outcome in depression. At completion
of the neuroimaging task, participants will enter a placebo-controlled clinical trial with a
selective serotonin reuptake inhibitor (SSRI).