Neuroimaging GABA Physiology in Fragile X Syndrome
Status:
Terminated
Trial end date:
2018-12-06
Target enrollment:
Participant gender:
Summary
The investigators wish to compare the brain distribution of GABA(A) receptors and GABA levels
in young adult males with Fragile X Syndrome compared to idiopathic intellectual
developmental disorder. The radiopharmaceutical [18F]flumazenil has been used to study
GABA(A) receptor distribution in other genetic syndromes with autistic features; however,
despite overwhelming evidence supporting the importance of the GABAergic system in FXS, no
clinical investigation of this system in human FXS has been reported in the literature.
Therefore, this study will provide the first in vivo comprehensive examination of the
GABAergic system in FXS using hybrid positron emission tomography/ magnetic resonance imaging
(PET/MRI).