Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents With Anxiety
Status:
Completed
Trial end date:
2020-05-01
Target enrollment:
Participant gender:
Summary
Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents with Anxiety. To
determine the effects of escitalopram on functional activation patterns during a Continuous
Performance Task with Emotional and Neutral Distracters, the CPT-END. To examine baseline
functional activity and functional connectivity profiles in the ventrolateral prefrontal
cortex as markers of subsequent treatment response to escitalopram in adolescents with
generalized anxiety disorder (GAD). To use proton magnetic resonance spectroscopy (1H MRS) to
examine glutamatergic and γ-aminobutyric acid (GABA)-related abnormalities in the anterior
cingulate in adolescents with GAD as compared to healthy adolescents.