Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study was to address 3 short term objectives; (1) Determine the effects
of physiologic testosterone (T) therapy on neurological function and functional independence
following traumatic brain injury (TBI) in hypogonadal men during inpatient rehabilitation;
(2) Document the natural history of neuroendocrine dysfunction and recovery in men during
inpatient rehabilitation after TBI; (3) Obtain data to validate the NIH toolbox, a novel
assessment of neurological function for use in the TBI population; and 2 long-term
objectives: (1) Utilize study findings to design a multicenter trial to further assess the
impact of T therapy in hypogonadal men following TBI and (2) Impact TBI practice management
with new information about neuroendocrine dysfunction after TBI and hormone treatments to
improve outcomes.