Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients
Status:
Withdrawn
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
Restricting dietary lysine intake in infants from age 3 months or less with confirmed
diagnosis of pyridoxine-dependent epilepsy due to Antiquitin (ATQ) deficiency will: reduce
the accumulation of neurotoxic substratesα-aminoadipicsemialdehydeandits cyclic equivalent
1-piperideine-6-carboxylate;and will improve overall neurodevelopmental outcome at 3 years of
age by acting as an effective intervention into the complex pathophysiology of the condition.
Details
Lead Sponsor:
University of British Columbia
Collaborators:
British Columbia Childrens Hospital Foundation March of Dimes