Neurobehavioral Mechanisms of Cocaine Choice

• Status: Recruiting
• Trial end date: 2023-10-31
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during behavioral and pharmacological interventions.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Joshua A. Lile, Ph.D.; University of Kentucky
• Treatments: Amphetamine; Cocaine; Dextroamphetamine

Criteria

Inclusion Criteria:

• Recent cocaine use, otherwise healthy

Exclusion Criteria:

• Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease