Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
The objective of this protocol is to use probabilistic reinforcement learning choice tasks
and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and
opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and
neurobiological processes underlying abnormal task performance. A second objective is to
identify an appropriate dose of intravenous remifentanil for subsequent studies in physically
dependent individuals with opioid use disorder.