Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Status:
Not yet recruiting
Trial end date:
2027-06-01
Target enrollment:
Participant gender:
Summary
This study will determine the effects of pregnenolone on brain function, inflammation and
depressive symptoms in people living with HIV who have depression. Participants in this study
will receive a pill of either pregnenolone or placebo, and can stay on their current
antidepression medications. Brain imaging and behavioral assessments will be performed during
the study.
Phase:
Phase 2
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborators:
Institute for Medical Research, Inc. National Institute of Mental Health (NIMH)