Neuro-Ox 2018: Assessment of Cerebral Oxygenation Under Three Clinically Relevant Conditions
Status:
Completed
Trial end date:
2020-10-01
Target enrollment:
Participant gender:
Summary
This is a prospective observational study, consisting of 3 substudies carried out during
elective neurosurgery under general anaesthesia. Each participant will take part in all 3
substudies. First, the capability of Near Infra Red Spectroscopy (NIRS) to measure the brain
oxygenation is examined. A NIRS-electrode is placed on forehead skin, on the skull, and on
dura. Secondly, a small dose of Phenylephrine is given, and the brain oxygenation is measured
by a Clark-electrode and a NIRS-electrode, to see how Phenylephrine affects these
measurements. In the third substudy, the brain oxygenations' (NIRS and Licox) response to an
inspired oxygen fraction of 0.30 vs. 0.80 is investigated.