Forty 18-year-old social drinkers will be selected from the sample tested in specific aim 1
("Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted
Self-administration of Ethanol (CASE)"; ClinicalTrials.gov identifier: NCT01063166). The
functional magnetic resonance imaging blood-oxygen-level-dependent (fMRI BOLD) activity
related to disinhibition measured with the Stop Signal task will be assessed during a
continuous infusion of alcohol, clamping the arterial Breath Alcohol Concentration (aBAC) at
60 mg% for approximately one hour. It will be examined whether this fMRI BOLD activity is
associated with the initial drinking trajectories and the alcohol consumption at age 18 and
at age 20 identified in specific aim 1. Furthermore, fMRI will be used with the Taylor
Aggression Paradigm to determine which brain areas mediate increased physical aggression
during the same continuous infusion of alcohol as described above. All participants will
undergo an alcohol and a placebo fMRI session.