Overview Neural Circuit Effects of Ketamine in Depression Status: RECRUITING Trial end date: 2028-04-30 Target enrollment: Participant gender: Summary This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketamine on agACC activation and depression symptoms.Phase: PHASE4 Details Lead Sponsor: Icahn School of Medicine at Mount SinaiCollaborator: National Institute of Mental Health (NIMH)Treatments: Ketamine