Nesiritide and Renal Function After the Total Artificial Heart
Status:
Terminated
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
The prevalence of renal dysfunction after implantation of the artificial heart is high. The
infusion of exogenous B-type natriuretic peptide (BNP) after implantation of the total
artificial heart (TAH) improves renal function in a sustained manner. The renal protective
and hormone-modulating effects of nesiritide may be enhanced with ventriculectomy compared to
heart failure surgery that leaves the native myocardium intact. The goal of this project is
to determine the renal protective effects of nesiritide after implantation of a mechanical
device.